System Not Yet Approved for Sale in the US or the EU.


4 veils of plasma being examined by a scientist.

Introduction to FrontlineODP™

FrontlineODP™ Spray Dried Plasma is designed for easy integration in blood center component laboratories. Decentralized production by blood centers would leverage deep blood component manufacturing expertise and product supply chains, from established volunteer blood donor bases to end user distribution including emergency logistic channels.
Decentralized production would establish local dry plasma self-sufficiency and availability for national emergency preparedness including civilian, government and military collaboration for strategic stockpiles and readiness for mass casualty events.
Applications in Industry
The FrontlineODP™ system is intended to be deployed at blood centers that will produce dry plasma for use by hospitals, emergency first responders and the military.

Potential to address traumatic bleeding following major disasters.

Readily rehydrates within minutes, making it practical in prehospital settings where conventional plasma is unavailable or impractical.

Lightweight and compact in design, would support ease of use, overcoming the logistical challenges of frozen or thawed plasma, and enabling early transfusion at the point of injury.

Rapid reconstitution process has the potential to allow first responders to act fast in trauma settings.

Value & Potential Benefits of FrontlineODP™
Pivotal studies show that early transfusion of plasma improves patient outcomes and prevents unnecessary death from bleeding in military and civilian situations
During mass casualty events, logistical challenges limit the ability to deliver conventional plasma transfusions
FrontlineODP™ is portable and designed for ease of use with a potential shelf life of 2 years
Ability to deliver early, point of care transfusions could help save lives

Why is it needed?

Studies have shown prehospital transfusions for those who have suffered a significant hemorrhage is life saving. When transport to a hospital setting is delayed, prehospital transfusions have the potential to save over 33% of patients suffering from traumatic hemorrhage.

Logistical constraints limit the ability to deliver early transfusions when casualties happen in austere, military environments or remote settings. Alternative products are urgently needed for use in logistically challenging environments, when standard transfusions are delayed. Dried plasma has the potential to help to save lives in both military and civilian settings.

Velico’s FrontlineODP™ Business Model

Velico’s business model will be based on partnerships with regional blood centers which collect, test and manufacture lifesaving blood components every day. Velico’s FrontlineODP™ system is being designed for straight-forward integration into existing blood centers.

The FrontlineODP™ development program is funded by the Biomedical Advanced Research and Development Authority (BARDA), within the Office of the Assistant Secretary for Preparedness and Response in the U.S. Department of Health and Human Services under contract No. 75A50121C00059. 

Rehydrated Plasma

Resulting Plasma

Velico is developing FrontlineODP™, a novel, platform technology for manufacturing spray dried human plasma. The FrontlineODP™ system is intended to be deployed at regional blood centers that will produce dry plasma for use by hospitals, emergency first responders and the military. Dry plasma overcomes the logistics of conventional frozen plasma and potentially extends the availability of plasma closer to the point of injury, including rural and austere settings. The resulting plasma units are compact and can be stored either refrigerated or at room temperature.


FrontlineODP™ is easily reconstituted with 200 ml of sterile water for injection (SWFI), and ready for use within minutes, making it practical in prehospital settings where conventional plasma is unavailable.


Uncontrolled hemorrhage is recognized as the leading cause of potentially preventable death among victims of trauma.† The early administration of plasma has been shown to be lifesaving for many of these patients.

† Sperry JL, et al. Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock. N Engl J Med. 2018 Jul 26;379(4):315-326

Want to learn more?

If you are a blood center, hospital, investor or interested in learning more about Velico, please click the button below to submit a request.