System Not Yet Approved for Sale in the US or the EU.


4 veils of plasma being examined by a scientist.

Introduction to FrontlineODP™

FrontlineODP™ Spray Dried Plasma is designed for easy integration in blood center component laboratories. Decentralized production by blood centers would leverage deep blood component manufacturing expertise and product supply chains, from established volunteer blood donor bases to end user distribution including emergency logistic channels.
Decentralized production would establish local dry plasma self-sufficiency and availability for national emergency preparedness including civilian, government and military collaboration for strategic stockpiles and readiness for mass casualty events.
Applications in Industry
The FrontlineODP™ system is intended to be deployed at blood centers that will produce dry plasma for use by hospitals and medics.

Evidence shows effectiveness of early plasma transfusion for the prevention or correction of coagulopathy and hemorrhage in combat environments.

Lightweight and with reduced logistical requirements, FrontlineODP™ is designed to treat traumatic hemorrhage wherever needed, without the challenges or delays related to frozen plasma.

FrontlineODP™’s rapid reconstitution process would allow medics to respond quickly in battlefield settings, where current plasma options are not practical or available.

Value & Potential Benefits of FrontlineODP™
Pivotal studies show that early transfusion of plasma improves patient outcomes and prevents unnecessary death from bleeding in military and civilian situations
Ease of use in emergencies
Potential shelf life of 2 years
Light-weight, ruggedized plastic packaging
Rapid treatment of hemorrhaging patients

Why is it needed?

Hemorrhagic shock is the primary cause of death in combat. Data from the US army suggests early transfusion reduces mortality. Conventional fresh frozen plasma is impractical on the battlefield, as it requires thawing. Frozen plasma also presents storage and logistical challenges. FrontlineODP™ would be easy to transport, eliminates thawing delays, and can rehydrate and be ready for use within minutes.

Velico's® FrontlineODP™ Business Model

Velico's® business model will be based on partnerships with regional blood centers which collect, test and manufacture lifesaving blood components every day. Velico's® FrontlineODP™ system is being designed for straight-forward integration into existing blood centers.

The FrontlineODP™ development program is funded by the Biomedical Advanced Research and Development Authority (BARDA), within the Office of the Assistant Secretary for Preparedness and Response in the U.S. Department of Health and Human Services under contract No. 75A50121C00059. 

Rehydrated Plasma

Resulting Plasma

Velico® is developing FrontlineODP™, a novel, platform technology for manufacturing spray dried human plasma. The FrontlineODP™ system is intended to be deployed at regional blood centers that will produce dry plasma for use by hospitals, emergency first responders and the military. Dry plasma overcomes the logistics of conventional frozen plasma and potentially extends the availability of plasma closer to the point of injury, including rural and austere settings. The resulting plasma units are compact and can be stored either refrigerated or at room temperature.


FrontlineODP™ is easily reconstituted with 200 ml of sterile water for injection (SWFI), and ready for use within minutes, making it practical in prehospital settings where conventional plasma is unavailable.


Uncontrolled hemorrhage is recognized as the leading cause of potentially preventable death among victims of trauma.† The early administration of plasma has been shown to be lifesaving for many of these patients.

† Sperry JL, et al. Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock. N Engl J Med. 2018 Jul 26;379(4):315-326

Want to learn more?

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